Mood Rx: The Top 2 Peptides to Help Change Your Brain Chemistry

If you’ve been feeling mentally foggy, emotionally flat, anxious, or just off - you’re not alone.

And yet, too often the only option presented is a prescription that may blunt your feelings, lower your libido, and leave you feeling like a dimmed-down version of yourself.

At TeleWellnessMD, we take a different approach.

We believe that when it comes to brain health and emotional wellness, it’s important to look beyond the symptoms - and get to the root of what’s really going on. Things like chronic stress, inflammation, mitochondrial fatigue, and an overworked nervous system may all contribute to how you feel mentally and emotionally.

That’s where peptides may help.

We don’t treat disease. We support wellness by helping your body - and your brain - get what it needs to function more optimally.

Here are two peptides that may support mood, focus, and cognitive resilience:

Selank - For Calm, Focused Mental Clarity

Selank is a synthetic peptide derived from tuftsin, a naturally occurring immune molecule. It was originally developed to support stress resilience in high-performance settings - and today, it’s used by individuals looking for calm and clarity without sedation or fog.

Potential benefits may include:

• Supporting healthy dopamine and serotonin levels

• Promoting a balanced stress response (lowering excess cortisol)

• Encouraging GABA activity for a sense of calm and focused thinking

• Supporting emotional regulation and sleep quality

How it’s typically used:
300 mcg intranasally, once or twice daily. May be helpful for those navigating daily stress, burnout, or emotional rebalancing.

Backed by research:
Preclinical studies suggest Selank may offer anxiolytic-like effects similar to traditional medications, but without the sedating or habit-forming properties. It may also play a role in cognitive and immune support.

Dihexa - For Mental Energy and Cognitive Support

Dihexa is a neuroactive peptide developed to support brain health, with research exploring its potential in conditions like Alzheimer’s and traumatic brain injury. It’s gained attention for its ability to promote brain plasticity and support emotional well-being.

Potential benefits may include:

• Supporting synaptogenesis (the formation of new neural connections)

• Increasing levels of BDNF, a key factor in brain growth and resilience

• Supporting mood, memory, and cognitive energy

• Helping the brain recover from chronic stress or neuroinflammation

How it’s typically used:
Taken orally (4–10 mg daily) or applied transdermally in cycles of 8–12 weeks. Often explored by those recovering from emotional fatigue, cognitive burnout, or long-term stress.

Backed by research:
Animal studies suggest Dihexa may be more potent than BDNF itself in supporting neural regeneration. Early findings also indicate it may support memory, emotional processing, and brain repair.

Peptides Aren't a Quick Fix - They're a Smarter Strategy

We don’t believe in masking how you feel. Our goal is to support your body’s natural chemistry - so you can think more clearly, feel more balanced, and function at your best.

And because no two people are the same, every peptide protocol at TeleWellnessMD is personalized - based on your labs, goals, and how you want to feel.

Ready to explore a more personalized approach to mental wellness?

Our licensed providers will guide you through the process, from lab testing to peptide selection and ongoing support.

Book your consult today. It might just be the first step toward feeling more like you again.